Description
Mysimba: The Oral Tablet Alternative for Weight Loss
Mysimba is the leading oral weight loss tablet licensed in Europe — a once-daily pill that combines two well-established medications: naltrexone and bupropion. For patients who prefer not to inject, can’t tolerate GLP-1 medications, or have specific medical reasons to avoid them, Mysimba offers a clinically-validated alternative with average weight loss of 5–9% over 56 weeks in trials. EU Slim Store offers Mysimba prescribed by Dutch BIG-registered doctors after a free online consultation.
How Mysimba Works — A Different Mechanism Entirely
Unlike GLP-1 medications, which mimic gut hormones, Mysimba targets the brain’s hunger and reward systems directly. The two active ingredients work together:
- Naltrexone — an opioid receptor antagonist that disrupts the reward response your brain gets from food, especially high-fat and high-sugar foods
- Bupropion — a noradrenaline and dopamine reuptake inhibitor that increases satiety signals and reduces food-focused thoughts
Together, the combination targets both the want (reward) and need (hunger) drivers of overeating. This is fundamentally different from GLP-1 medications, which target gut hormones and stomach emptying.
Who Should Consider Mysimba?
Mysimba is licensed for adults with:
- BMI ≥ 30 (obesity), or
- BMI ≥ 27 with at least one weight-related condition (type 2 diabetes, dyslipidaemia, hypertension)
Mysimba may be particularly appropriate for patients who:
- Prefer tablets over injections
- Are struggling with food-reward cravings (carbohydrates, sweets, snacks)
- Have not tolerated GLP-1 medications due to nausea
- Have depression or smoking cessation goals (bupropion treats both)
Mysimba is NOT appropriate for patients with: uncontrolled hypertension, history of seizures, eating disorders (especially bulimia or anorexia), severe liver or kidney disease, chronic opioid use, or use of MAOI antidepressants in the previous 14 days.
Every individual’s weight management journey is different. Depending on your health goals, lifestyle preferences, and treatment eligibility, you may wish to explore other weight loss options available. Popular alternatives include GLP-1 treatments such as Wegovy®, Mounjaro®, Biolide® Daily Injection (Liraglutide), and Plaobes® Daily Injection (Liraglutide), as well as capsule-based treatments like Xenical®, Orlos®, and Alli®.
Mysimba Dosing Schedule
Mysimba uses a four-week titration to gradually build up to the maintenance dose:
- Week 1: 1 tablet in the morning (8 mg naltrexone / 90 mg bupropion)
- Week 2: 1 tablet morning, 1 evening (16 mg / 180 mg total daily)
- Week 3: 2 tablets morning, 1 evening (24 mg / 270 mg total daily)
- Week 4+: 2 tablets morning, 2 evening (32 mg / 360 mg total daily — maintenance)
Take with food but avoid high-fat meals, which significantly increase absorption and side effects. Swallow whole — do not crush, split, or chew.
Side Effects of Mysimba
The most common side effects:
- Nausea (~32% during titration)
- Constipation (~19%)
- Headache (~17%)
- Insomnia or vivid dreams (~13%) — take morning dose early
- Dry mouth (~8%)
- Dizziness or anxiety
Most side effects fade within 4 weeks. If insomnia persists, taking the evening dose earlier (with dinner instead of bedtime) usually helps.
Important warnings:
- Mysimba can increase blood pressure and heart rate. Your doctor will monitor and may discontinue if uncontrolled hypertension develops.
- Bupropion lowers seizure threshold. Mysimba is contraindicated if you have a seizure history.
- Suicidal thoughts and behaviour changes have been reported with bupropion-containing medications. Stop the medication and contact your doctor immediately if you experience worsening mood, anxiety, agitation, or thoughts of self-harm.
Mysimba vs. GLP-1 Medications
| Feature | Mysimba | GLP-1 (Wegovy/Mounjaro) |
|---|---|---|
| Form | Oral tablet | Injection |
| Frequency | Daily | Weekly |
| Average weight loss | 5–9% | 14.9–20.9% |
| Mechanism | Brain reward + satiety | Gut hormone + appetite |
| Best for | Food reward cravings | Hunger-driven overeating |
Mysimba is less effective on average than GLP-1 medications for total weight loss, but it works through a different mechanism that suits certain patients better — particularly those with strong food reward / cravings as the primary issue rather than physical hunger.
How to Buy Mysimba Online
- Complete the free five-minute consultation
- Dutch BIG-registered doctor reviews within 24 hours — particular attention to blood pressure, mental health history, seizure risk
- Prescription issued if appropriate
- IGJ-registered Dutch pharmacy dispenses Mysimba in original packaging
- PostNL delivery in 3–5 working days in discreet packaging
Storage
Store Mysimba tablets at room temperature (below 30 °C) in the original blister packaging. No refrigeration required.
Pricing
Mysimba from EU Slim Store starts at €68 per month, all-inclusive: medication, doctor consultation, pharmacy dispensing, and PostNL delivery. Mysimba is our most affordable prescription weight loss treatment.
Get Started
If you’d prefer an oral tablet over an injection, take the free five-minute consultation now. Doctor response within 24 hours.
English 
German 
Spanish 
Dutch 
Polish 
French 
Norwegian
There are no reviews yet.